BDBM5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870
SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
InChI Key InChIKey=AAKJLRGGTJKAMG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 5446
Affinity DataIC50: 760nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 7.5Assay Description:The EGFR, HER2 and HER4 kinase assay were performed using radiolabeled [gamma-32P] ATP from GE Healthcare. More data for this Ligand-Target Pair
Affinity DataKd: 5.10E+3nMAssay Description:Average Binding Constant for ERBB2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of histidine-tagged recombinant HER2 (unknown origin) expressed in Sf9 cells assessed as reduction in enzyme autophosphorylation by DELFIA...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of His-tagged human HER-2 cytoplasmic domain (676-1245 aa) (unknown origin) assessed as inhibition of autophosphorylation by TR-fluorometr...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Her2 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of HER2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human cloned HER2 autophosphorylation expressed in baculovirus-infected Sf9 cells by solid-phase ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human cloned HER2 autophosphorylation expressed in baculovirus-infected Sf9 cells by solid-phase ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant HER2 expressed in Sf9-baculovirus system by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of ErbB2 by time resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.73E+3nMAssay Description:Inhibition of ERBb2 phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of HER2 by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant (His)6-tagged HER-2 autophosphorylation pre-incubated for 10 mins by DELFIA/Time-resolved fluorometryMore data for this Ligand-Target Pair
Affinity DataKd: 2.90E+3nMAssay Description:Binding constant for ERBB2 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of Erbb2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of Her-2 by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of human epidermal growth factor receptor-2 autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 511nMAssay Description:Inhibition of erbB2 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 299nMAssay Description:Inhibition of ligand stimulated erbB2 autophosphorylation in T24 NIH cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human HER2 cytoplasmic domain (amino acids 676 to 1245) expressed in Sf9 cells by DELFIA time resolved fluorometryMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant HER-2 cytoplasmic domain (676 to 1245) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERBB2 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant His6x-tagged HER2 autophosphorylation expressed in Sf9 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human His-tagged HER2 cytoplasmic domain (676 to 1255 residues) expressed in baculovirus virus expression system after 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human GST-tagged HER2 (676-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP ...More data for this Ligand-Target Pair
Affinity DataIC50: 369nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide substrate preincubated for 10 mins followed by substrate addition measured after 40 min...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 G...More data for this Ligand-Target Pair
Affinity DataIC50: 369nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
Affinity DataIC50: 513nMAssay Description:Inhibition of EGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of human HER2 incubated for 1 hrs in presence of ATP by ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of HER2 (unknown origin) incubated for 1 hrs by ELISA assayMore data for this Ligand-Target Pair